Carbohydrate Related Perspective – Article Example
Carbohydrate related perspective In the article, hepatic expression and cellular distribution of the glucose transporter family, a regular supply of glucose and carbohydrates is fundamental for human survival. Members of a family of integral membrane (GLUT) glucose transporter molecules transport the glucose and carbohydrates into cells. The liver is a key site for production, storage and redistribution of carbohydrates. In addition, it is a contributor to carbohydrate metabolic homeostasis. GLUTs takes up glucose after a meal from access bloodstream and, it is then changed to glycogen for storage. Consequently, the glycogen is converted back to glucose during glucose-depleted state. Situations in which glucose homeostasis balance is not appropriate, it can lead to metabolic disturbances, which cause chronic damage failure.
According to the article, carbohydrate is needed for cells to function. In addition, it shows how systemic carbohydrate homeostasis is maintained by a complex bond between organs such as the intestine, muscle, pancreas and liver. Another issue is how pathogenesis diseases can be understood by better understanding cellular distribution of GLUTs in human liver tissue. This is not entirely factual; therefore extensive research needs to be done on extraheptic transporter function to the liver and protein expression proteins. It is also, not clear how there is a direct link between liver tissues and pathogenic diseases. Moreover, there are gaps that need to be filled so as to ascertain how significant carbohydrate is in cell functioning.
From this article, it is clear that they are over ten different types of glucose transporters. However, the peer review literature can support the discussion that GLUT 1 -4 transporters are the most significant of the ten glucose transporters. GLUT 1 and 3 play big roles as they are located throughout the body in plasma membrane and are responsible for maintaining basal rate of glucose. GLUT 2 in contrast has a high Km value hence low glucose affinity. GLUT 4 transporters are sensitive on insulin and are found in adipose and muscle tissue.
Karim, S., Lalor, P. F., & Adams, D. H. (2012). Hepatic expression and cellular distribution of
the glucose transporter family. World J Gastroenterology, 18.(46), 6771–6781. Retrieved January 28, 2013, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520166